发明名称 |
Substituted Aryl-Indole Compounds and Their Kynurenine/Kynuramine-Like Metabolites As Therapeutic Agents |
摘要 |
This invention is directed to substituted aryl compounds, which are linked to a substituted indole moiety by various linkers, and the kynurenine/kynuramine-like metabolites of these agents, their preparation and pharmaceutical compositions containing these compounds. This invention further is directed to the pharmaceutical use of the compounds for inhibiting GSK3&bgr; kinase and/or modulating N-methyl-D-aspartate (NMDA) channel activities for the treatment of neurodegenerative and other disorders.
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申请公布号 |
US2010048663(A1) |
申请公布日期 |
2010.02.25 |
申请号 |
US20090611373 |
申请日期 |
2009.11.03 |
申请人 |
NEURIM PHARMACEUTICALS (1991) LTD. |
发明人 |
PELEG-SHULMAN TAL;LAUDON MOSHE;DAILY DORAH |
分类号 |
A61K31/404;A61K31/135;A61P3/10;A61P25/00;A61P29/00;A61P35/00;C07C211/43;C07D209/04 |
主分类号 |
A61K31/404 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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