COMPOSITIONS AND METHODS FOR GENERATION OF PLURIPOTENT STEM CELLS

摘要

The present invention describes the use of pre-trans-splicing molecules (PTMs) to reprogram human normal and diseased somatic cells into pluripotent stem cells using spliceosome-mediated RNA trans-splicing. More specifically, the present invention describes the use of the SMaRT technology to repair or reprogram the newly induced diseased pluripotent stem cells.