发明名称 |
Bicyclic nitroimidazole-substituted phenyl oxazolidinones |
摘要 |
The current invention provides a series of bicyclic nitroimidazole-substituted phenyl oxazolidinones in which a bicyclic nitroimidazole pharmacophore is covalently bonded to a phenyl oxazolidinone, their pharmaceutical compositions, and the method of use of the compositions for prevention and treatment of bacterial infections. The bicyclic nitroimidazole-substituted phenyl oxazolidinones possess surprising antibacterial activity against wild-type and resistant strains of pathogens, and are therefore useful for the prevention, control and treatment of a number of human and veterinary bacterial infections caused by these pathogens, such as Mycobacterium tuberculosis.
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申请公布号 |
US7666864(B2) |
申请公布日期 |
2010.02.23 |
申请号 |
US20090411220 |
申请日期 |
2009.03.25 |
申请人 |
GLOBAL ALLIANCE FOR TB DRUG DEVELOPMENT |
发明人 |
DING CHARLES Z.;LU GENLIANG;COMBRINK KEITH;CHEN DIANJUN D.;SONG MINSOO;WANG JIANCHENG;MA ZHENKUN;PALMER BRIAN DESMOND;BLASER ADRIAN;THOMPSON ANDREW M.;KMENTOVA IVETA;SUTHERLAND HAMISH SCOTT;DENNY WILLIAM ALEXANDER |
分类号 |
C07D498/04;A61K31/424;A61K31/5365;A61K31/553 |
主分类号 |
C07D498/04 |
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