发明名称 |
TETRAHYDROISOQUINOLIN-1-ONE DERIVATIVE OR SALT THEREOF |
摘要 |
[PROBLEMS] To provide a compound which can be used as a medicinal agent, particularly a therapeutic agent for irritable bowel syndrome (IBS). [MEANS FOR SOLVING PROBLEMS] It is found that a tetrahydroisoquinolin-1-one derivative having an amide group at position-4 or a pharmaceutically acceptable salt thereof has an excellent antagonistic activity on a bombesin-2 (BB2) receptor. It is also found that the tetrahydroisoquinolin-1-one derivative is highly effective on stool abnormality. Therefore, the tetrahydroisoquinolin-1-one derivative is useful as a therapeutic agent for a disease associated with a BB2 receptor, particularly IBS. |
申请公布号 |
KR20100020982(A) |
申请公布日期 |
2010.02.23 |
申请号 |
KR20097027024 |
申请日期 |
2008.05.26 |
申请人 |
ASTELLAS PHARMA INC. |
发明人 |
HISAMICHI HIROYUKI;SHIMADA ITSURO;ISHIHARA TSUKASA;TAKUWA TOMOFUMI;SHIMIZU TAKAFUMI;ISHIKAWA NORIKO;MAENO KYOICHI;SEKI NORIO |
分类号 |
C07D217/26;A61K31/472;A61P35/00;C07D409/12 |
主分类号 |
C07D217/26 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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