发明名称 |
Mutant interferonαprotein and use thereof |
摘要 |
The present invention has objects to provide a mutant interferon-α protein having a higher anti-viral and anti-tumor activity and to provide an agent for susceptive diseases, which contains the mutant interferon-α protein as an effective ingredient; and solves the above objects by providing a mutant protein which has an amino acid sequence of human interferon-α subtype α8 represented by any one of SEQ ID NOs:1 to 3, where the arginine residue at the 145th has been replaced with leucine, isoleucine, or valine residue; the alanine residue at the 146th has been replaced with asparagine or serine residue; and the methionine residue at the 149th has been replaced with tyrosine residue; and an agent for susceptive diseases, containing the mutant protein.
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申请公布号 |
US7666403(B2) |
申请公布日期 |
2010.02.23 |
申请号 |
US20050719283 |
申请日期 |
2005.11.09 |
申请人 |
KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO |
发明人 |
MAYUMI TADANORI;TSUTSUMI YASUO;NAKAGAWA SHINSAKU;TANIAI MADOKA;TORIGOE KAKUJI;KURIMOTO MASASHI |
分类号 |
C07K14/52;A61K38/21;C12N15/21 |
主分类号 |
C07K14/52 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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