EFFICIENT CELL CULTURE SYSTEM FOR HEPATITIS C VIRUS GENOTYPE 2B
摘要
<p>The present inventors developed hepatitis C virus 2b/2a intergenotypic recombinants in which the JFH1 structural genes (Core, E1 and E2), p7 and the complete NS2 were replaced by the corresponding genes of the genotype 2b reference strain J8. Sequence analysis of recovered 2b/2a recombinants from 2 transfection experiments revealed that 2b/2a was genetically stable. Conclusion: The developed 2b/2a viruses provide a robust in vitro tool for research in HCV genotype 2b, including vaccine studies and functional analyses.</p>
申请公布号
WO2010017818(A1)
申请公布日期
2010.02.18
申请号
WO2009DK50189
申请日期
2009.07.24
申请人
HVIDOVRE HOSPITAL;GOTTWEIN, JUDITH M.;KNUDSEN, MARIA L.;SCHEEL, TROELS KASPER HOEYER;BUKH, JENS
发明人
GOTTWEIN, JUDITH M.;KNUDSEN, MARIA L.;SCHEEL, TROELS KASPER HOEYER;BUKH, JENS