AZACARBOLINE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF AS KINASE INHIBITORS

摘要

The invention relates to novel azacarbolines having formula (I), wherein R3, R4 independently represent H, hal, CF3, substituted oxy, optionally substituted alkoxy, optionally substituted amino, substituted carbonyl, optionally substituted carboxyl, optionally substituted amide, sulphur, such as optionally substituted sulphides, sulphoxides or sulphones, linear, branched or cyclic C1-C10 alkyl optionally comprising an optionally substituted heteroatom, optionally substituted linear, branched or cyclic C2-C7 alkenyl, optionally substituted linear or branched C2-C6 alkynyl, optionally substituted aryl or heteroaryl, optionally substituted heterocycloalkyl, R6 represents heteroaryl, C(O)NR1aR1b, heterocycloalkyl or -C(O)heterocycloalkyl, all of which may be optionally substituted; in the form of a base or an acid addition salt. The invention also relates to the therapeutic use of said azacarbolines for the treatment of cancer and to synthesis methods.