发明名称 |
VECTORS FOR MULTIPLE GENE EXPRESSION |
摘要 |
The present invention provides a vector for expressing at least a first and a second nucleic acid molecules which exhibit a percentage of homology of approximately 80% or greater than 80% over a portion of 40 or more continuous nucleotides and wherein said first nucleic acid molecule and/or said second nucleic acid molecule is modified so as to reduce said percentage of homology to less than 75%. The present invention also relates to substantially isolated nucleic acid molecules comprising a nucleotide sequence as defined in any of SEQ ID NO: 9-15 and 66-69. It also provides a host cell and a pharmaceutical composition comprising such a nucleic acid molecule or vector as well as their use for therapeutic or preventive purposes.
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申请公布号 |
KR20100019432(A) |
申请公布日期 |
2010.02.18 |
申请号 |
KR20097023308 |
申请日期 |
2008.01.29 |
申请人 |
TRANSGENE S.A. |
发明人 |
SILVESTRE NATHALIE;SCHMITT DORIS |
分类号 |
C12N15/86;A61K48/00;C12N15/861;C12N15/863 |
主分类号 |
C12N15/86 |
代理机构 |
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