发明名称 |
COMPOSITION AND METHODS FOR THE DESIGN AND DEVELOPMENT OF METALLO-ENZYME INHIBITORS |
摘要 |
The present disclosure provides compounds having the general structure A or pharmaceutically acceptable salts thereof: R—X  (A) wherein R is an alkyl or aryl moiety comprising heterocyclic structures; and X is a metal-chelatin group selected from: This disclosure further provides a focused library of compounds for use in the discovery and design of metallo-enzyme inhibitors. This fragment-based approach provides an assembly of a library of low molecular weight compounds (MW<300 Da) containing a variety of potential metal-chelating groups. The identification of the inhibitory scaffolds among these compounds provides the initial hit fragments that may be optimized for affinity against a particular target using common medicinal chemistry, structure-based or NMR-based approaches.
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申请公布号 |
US2010041653(A1) |
申请公布日期 |
2010.02.18 |
申请号 |
US20090541871 |
申请日期 |
2009.08.14 |
申请人 |
BURNHAM INSTITUTE FOR MEDICAL RESEARCH;THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
PELLECCHIA MAURIZIO;COHEN SETH M. |
分类号 |
A61K31/5377;A61K31/44;A61K31/47;A61K31/4965;A61K31/505;C07D213/78;C07D215/00;C07D239/02;C07D241/02;C07D413/04 |
主分类号 |
A61K31/5377 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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