发明名称 |
HUMANIZED MONOCLONAL ANTIBODIES THAT SPECIFICALLY BIND AND/OR NEUTRALIZE JAPANESE ENCEPHALITIS VIRUS( (JEV) AND THEIR USE |
摘要 |
Disclosed herein are isolated humanized monoclonal antibodies that specifically bind Japanese encephalitis virus (JEV) with a binding affinity of about 1.0 nM or less. Nucleic acids encoding these antibodies, expression vectors including these nucleic acid molecules, and isolated host cells that express the nucleic acid molecules are also disclosed. Methods of treating, preventing, and/or ameliorating JEV infection in a subject with JEV also are disclosed. Additionally, the antibodies can be used to detect JEV in a sample, and methods of diagnosing JEV infection, or confirming a diagnosis of JEV infection in a subject, are disclosed herein that utilize these antibodies. |
申请公布号 |
WO2009126898(A3) |
申请公布日期 |
2010.02.18 |
申请号 |
WO2009US40227 |
申请日期 |
2009.04.10 |
申请人 |
THE GOVERNMENT OF THE U.S.A. AS REPRESENTED BY THE SECRETARY OF THE DEPT.OF HEALTH & HUMAN SERVICES;GONCALVEZ, ANA, P.;PURCELL, ROBERT, H.;LAI, CHING-JUH |
发明人 |
GONCALVEZ, ANA, P.;PURCELL, ROBERT, H.;LAI, CHING-JUH |
分类号 |
C07K16/18;A61K38/17;C12N15/13;G01N33/53 |
主分类号 |
C07K16/18 |
代理机构 |
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代理人 |
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