摘要 |
The invention provides transgenic, non-human animals comprising a nucleic acid encoding an immunoglobulin light chain, whereby the immunoglobulin light chain is human, human-like, or humanized. The nucleic acid is provided with a means that renders it resistant to DNA rearrangements and/or somatic hypermutations. In one embodiment, the nucleic acid comprises an expression cassette for the expression of a desired molecule in cells during a certain stage of development in cells developing into mature B cells. The invention further provides methods for producing an immunoglobulin from the transgenic, non-human animal. |
申请人 |
MERUS B.V.;HOUTZAGER, ERWIN;PINTO, RUI DANIEL;LOGTENBERG, TON;THROSBY, MARK;KRAMER, ROBERT, ARJEN;DE KRUIF, CORNELIS, ADRIAAN |
发明人 |
HOUTZAGER, ERWIN;PINTO, RUI DANIEL;LOGTENBERG, TON;THROSBY, MARK;KRAMER, ROBERT, ARJEN;DE KRUIF, CORNELIS, ADRIAAN |