摘要 |
The invention provides methods and compositions for determining whether an individual is at risk of developing, or has, one or more angiogenic disorders. The methods detect the presence and/or amount of one or more genes or gene products in a sample, including a RORA, CRIMl, CXCR4, C5orf26, IGHG3, NALP2, PLA2G4A, IGLJ3, SHQl, UCHLl, TANCl, PKP2, DNAJC6, C6orfl05, NALPl, RGS13, CXCL13, RPS6KA2, MMP7, ILIA, ABCAl, VCAN, KIAAO888, ENPP2, and FAM38B gene or gene product. In addition, the invention provides methods for using one or more of these genes or gene products as a target for preventing or delaying the onset of one or more angiogenic disorders or treating a patient with one or more such disorders. The angiogenic disorder can be, for example, an ocular angiogenic disorder, for example, a disorder associated with choroidal neovascularization, for example, age-related macular degeneration. |
申请人 |
MASSACHUSETTS EYE AND EAR INFIRMARY;THE ROCKEFELLER UNIVERSITY;DEANGELIS, MARGARET, M.;JI, FEI;OTT, JURG |
发明人 |
DEANGELIS, MARGARET, M.;JI, FEI;OTT, JURG |