METHODS FOR IDENTIFYING COMPOUNDS WHICH INHIBIT BINDING OF ANTHRAX PROTEIN TO LRP5/6 RECEPTORS

摘要

The present invention identifies compounds that disrupt the interaction between anthrax proteins and LRP5/6 receptors, resulting in a reduction in anthrax toxicity. The compounds act to disrupt the intracellular transport of toxin complexes into a target cell. The present invention also provides methods for testing the effect of compounds on Wnt activity, through the use of in vitro experiments involving cells that have in at least one gene mutation involved in the Wnt pathway.