<p>The present invention relates to domain antibodies which have modified framework regions such that the potency or level of binding of the domain antibody is improved. In particular the present invention relates to domain antibodies which bind TNF.alpha. in which changes have been made to framework sequences and to constructs including these domain antibodies.</p>
申请公布号
CA2733742(A1)
申请公布日期
2010.02.18
申请号
CA20092733742
申请日期
2009.08.13
申请人
CEPHALON AUSTRALIA PTY LTD
发明人
SIMPSON, RAINA JUI YU;ELGUNDI, ZEHRA;DOYLE, ANTHONY GERARD;JENNINGS, PHILIP ANTHONY;GAY, ROBERT DANIEL;CLARKE, ADAM WILLIAM
