发明名称 |
R-Hydroxynitrile Lyases Having Improved Substrate Acceptance and the Use Thereof |
摘要 |
R-hydroxynitrile lyases having an improved substrate acceptance, increased activity and increased selectivity, in which there is replacement in the amino acid sequence of R-hydroxynitrile lyases from the Rosaceae family either a) of the amino acid residue which corresponds to position 360 of the mature PaHNL5 protein by another apolar amino acid or a neutral amino acid and/or b) of the amino acid residue which corresponds to position 225 of the mature PaHNL5 protein by another polar amino acid, it also being possible where appropriate for 1 to 20 further residues in the active center or in the hydrophobic channel leading to the active center to be replaced.
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申请公布号 |
US2010041110(A1) |
申请公布日期 |
2010.02.18 |
申请号 |
US20050795685 |
申请日期 |
2005.12.28 |
申请人 |
WEIS ROLAND;GLIEDER ANTON;GRUBER KARL;SKRANG WOLFGANG;MAURER OLIVER;GAISBERGER RICHARD |
发明人 |
WEIS ROLAND;GLIEDER ANTON;GRUBER KARL;SKRANG WOLFGANG;MAURER OLIVER;GAISBERGER RICHARD |
分类号 |
C12P13/00;C12N9/88 |
主分类号 |
C12P13/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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