发明名称 |
Manipulation of Regulatory T Cell and Dc Function By Targeting Neuritin Gene Using Antibodies, Agonists and Antagonists |
摘要 |
We demonstrate herein that neuritin controls the homeostasis of regulatory T cells in an antigen dependent manner. Based on this discovery, we describe herein the application of neuritin as a therapeutic agent to manipulate antigen specific regulatory T cells in various disease settings is described. Thus manipulation of Treg cells and DCs through neuritin can be used to enhance immunotherapy of autoimmune diseases, cancer and infectious diseases, as well as enhance lymphocyte engraftment in settings of donor lymphocyte infusion, bone marrow transplant, as well as other types of transplants, and adoptive transfer.
|
申请公布号 |
US2010040636(A1) |
申请公布日期 |
2010.02.18 |
申请号 |
US20060991693 |
申请日期 |
2006.09.11 |
申请人 |
THE JOHNS HOPKINS UNIVERSITY |
发明人 |
YU HONG;PARDOLL DREW;PAN XIAOYA;DRAKE CHARLES GEORGE;POWELL JONATHAN D.;HUANG CHING-TAI |
分类号 |
A61K39/395;A01K67/027;A61K35/12;A61K38/16;A61P31/00;A61P35/00;A61P37/06;C07H21/00;C07K16/00;C12N15/63;C12Q1/02 |
主分类号 |
A61K39/395 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|