| 摘要 |
<p><P>PROBLEM TO BE SOLVED: To provide a method for producing a biaryl compound having tyrosinase inhibitory activity, useful as a skin-lightening agent. <P>SOLUTION: The biaryl compound represented by formula (3) is produced by reacting a methyl 6-methoxybenzoate derivative, boronated at the 5-position in which a hydroxy group at the 2-position is protected with a fixed protective group, with a 6-methylbenzyl bromide derivative in which hydroxy groups at the 2-position and the 4-position are protected with fixed protective groups, followed by deprotecting the resultant product. <P>COPYRIGHT: (C)2010,JPO&INPIT</p> |
