发明名称 |
MODIFIED GP140 ENVELOPE POLYPEPTIDES OF HIV-1 ISOLATES, COMPOSITIONS, STABILIZED TRIMERIC COPLEXES, AND USES THEREOF |
摘要 |
This invention provides a modified gp140 envelope polypeptide of an HIV-1 isolate comprising a gp120 polypeptide portion comprising consecutive amino acids and a gp41 ectodomain polypeptide portion comprising consecutive amino acids, said gp41 ectodomain polypeptide portion being modified to comprise isoleucine (I) at an amino acid position equivalent to amino acid position 535; glutamine (Q) at an amino acid position equivalent to amino acid position 543; serine (S) at an amino acid position equivalent to amino acid position 553; lysine (K) at an amino acid position equivalent to amino acid position 567; and arginine (R) at an amino acid position equivalent to amino acid position 588, the amino acid positions being numbered by reference to the HIV-1 isolate KNH1144. This invention also provides nucleic acids encoding such a polypeptide, vectors, host cells, trimeric complexes and compositions thereof. Also provided are antibodies generated against the modified polypeptides and trimeric complexes, and methods of using the modified polypeptides, compositions and trimeric complexes.
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申请公布号 |
US2010041875(A1) |
申请公布日期 |
2010.02.18 |
申请号 |
US20070312016 |
申请日期 |
2007.10.17 |
申请人 |
DEY ANTU K;JOHN MOORE P;OLSON WILLIAM C;IYER SAI PRASAD N;KANG YUN KENNETH;FRANTI MICHAEL |
发明人 |
DEY ANTU K.;JOHN MOORE P.;OLSON WILLIAM C.;IYER SAI PRASAD N.;KANG YUN (KENNETH);FRANTI MICHAEL |
分类号 |
C07K14/16;C07H21/04 |
主分类号 |
C07K14/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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