| 摘要 |
A formulation for a two-phase management of wound healing comprises a substrate containing a rapid release form of a first active agent in the form of an inclusion complex with a cyclic molecule, such as a cyclodextrin, the first active agent being accommodated in a cavity of the cyclic molecule, for rapid release of the first active agent on application of the formulation to a wound and at least one sustained release form of a second active agent which is released to the wound in response to a trigger by a wound constituent The formulation can be applied directly to a wound or formulated into a dressing for application to a wound. The formulation can be used in the treatment of both acute and chronic wounds and can be applied to all areas of the body. When the first and second active agents are each a pain relieving agent the formulation has particular application in a two-phase management of wound healing. |
