发明名称 |
ANTIBODY SPECIFIC FOR A POLYPEPTIDE ENCODED BY THE HUMAN PARKIN GENE AND A COMPOSITION COMPRISING IT |
摘要 |
New nucleic acid (I) encodes human parkin protein and includes at least one of the following genetic alterations: (a) deletion of one or more exons, optionally in combination; (b) multiplication of exons; (c) point mutations; or (d) deletion or insertion of one or more contiguous base pairs. Independent claims are also included for the following: (1) a polypeptide (II) encoded by (I); (2) an antibody (Ab) specific for (II); (3) a nucleic acid probe (Ia) that hybridizes specifically with (I); (4) primer pairs for amplifying all or part of (I); (5) a method for identifying genetic alterations in the parkin gene by amplifying at least part of the gene and detecting the specified alterations; (6) a method for diagnosing susceptibility to parkinsonism by detecting a specified alteration in the parkin gene; (7) a vector containing (I); (8) a cell containing the vector of (8); and (9) a non-human animal containing (I) in its cells. ACTIVITY : None given. MECHANISM OF ACTION : None given. No biological data given. |
申请公布号 |
IL187652(A) |
申请公布日期 |
2010.02.17 |
申请号 |
IL20070187652 |
申请日期 |
2007.11.26 |
申请人 |
AVENTIS PHARMA S.A.;INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE |
发明人 |
|
分类号 |
A01K67/027;A61K39/395;A61P25/06;C07K14/47;C07K16/18;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N9/00;C12N15/09;C12N15/12;C12Q1/68;G01N33/15;G01N33/50 |
主分类号 |
A01K67/027 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|