PDGFR-alpha antagonists for treatment of metastatic bone cancer

摘要

The present invention concerns an isolated human antibody or antibody fragment specific for PDGFRα comprising one or more complementarity determining regions selected from a group specified in the specification. The invention also relates to polynucleotides encoding the antibody or fragment thereof, expression vectors comprising such polynucleotides and recombinant host cells comprising the vectors. The antibodies may be used for inhibiting tumor growth in a mammal.