Therapeutic monoclonal antibodies that neutralize botulinium neurotoxins

摘要

This invention provides antibodies that specifically bind to and neutralize botulinum neurotoxin type A (BoNT/A) and the epitopes bound by those antibodies. The antibodies and derivatives thereof and/or other antibodies that specifically bind to the neutralizing epitopes provided herein can he used to neutralize botolinum neurotoxin and are therefore also useful in the treatment of botolism.