发明名称 |
FORMULATIONS CONTAINING CLOPIDOGREL AND SULFOALKYL ETHER CYCLODEXTRIN AND METHODS OF USE |
摘要 |
The present invention provides compositions containing clopidogrel, present as a free base or a pharmaceutically acceptable salt thereof, and sulfoalkyl ether cyclodextrin (SAE-CD). The compositions can be liquid, suspension or solid compositions. They can be adapted for oral, peroral or parenteral administration. The SAE-CD serves to aid in dissolution and stabilization of the clopidogrel in aqueous media. The stability of clopidogrel against hydrolytic degradation, thermal degradation, and photolytic degradation are improved. SAE-CD provides improved results over other cyclodextrin derivatives. The SAE-CD-containing composition of clopidogrel can be provided in liquid form, solid form or as a reconstitutable powder. Both ready-to-use and concentrated liquid compositions can be prepared. The liquid composition is optionally available as a clear solution. The compositions herein can be administered perorally or parenterally and provide substantial pharmacokinetic, pharmacodynamic and/or therapeutic advantages over a tablet composition administered perorally and excluding SAE-CD. |
申请公布号 |
EP2152078(A1) |
申请公布日期 |
2010.02.17 |
申请号 |
EP20080769199 |
申请日期 |
2008.04.26 |
申请人 |
CYDEX PHARMACEUTICALS, INC. |
发明人 |
MOSHER, GEROLD, L.;WEDEL, REBECCA, L.;JOHNSON, KAREN, T.;MACHATHA, STEPHEN, G.;COWEE, JANE, A.;CUSHING, DANIEL, J. |
分类号 |
A61K31/4365;A01N43/42;A61K31/44;A61K31/724;A61K31/727;A61K45/06;A61K47/40;A61K47/48 |
主分类号 |
A61K31/4365 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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