| 摘要 |
The present invention is directed to the process for the preparation of 2'-deoxy-2'-halo-.beta.-L-arabinofuranosyl nucleosides of formula (I), and in particular, 2'-deoxy-2'-fluoro-.beta.-L-arabinofuranosyl thymine (L-FMAU), from L-arabinose, which is commercially available and less expensive than L-ribose or L-xylose, in ten steps. All of the reagents and starting materials are inexpensive and no special equipment is required to carry out the reactions. (see formula I) wherein X is a halogen (F, Cl, Br or I); and B is a pyrimidine, purine, heterocyclic or heteroaromatic base.
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