发明名称 1,3-DIHYDROIMIDAZOLE-2-THIONE DERIVATIVES AS INHIBITORS OF DOPAMINE-BETA-HYDROXYLASE
摘要 Compounds of formula I and a method for their preparation are described, where R, Rand Rare the same or different and signify hydrogens, halogens, alkyl, nitro, amino, alkylcarbonylamino, alkylamino or dialkylamino group; Rsignifies-alkyl-aryl or alkyl heteroaryl;X signifies CH, oxygen atom or sulphur atom; n is 2 or 3; including the individual (R)-and (S)-enantiomers or mixtures of enantiomers thereof; and including pharmaceutically acceptable salts and esters thereof. The compounds have potentially valuable pharmaceutical properties for the treatment of cardiovascular disorders such as hypertension and chronic heart failure.
申请公布号 KR20100017546(A) 申请公布日期 2010.02.16
申请号 KR20097025071 申请日期 2008.05.06
申请人 BIAL - PORTELA & CA, S.A. 发明人 SOARES DA SILVA PATRICIO MANUEL VIEIRA ARAUJO;LEARMONTH DAVID ALEXANDER;BELIAEV ALEXANDER
分类号 C07D405/04;A61K31/4178;A61P25/22 主分类号 C07D405/04
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