发明名称 PIPERIDINES FOR USE AS OREXIN RECEPTOR ANTAGONISTS
摘要 Compounds of formula (I) wherein Y represents a group (CH2)n, wherein n represents 0, 1 or 2; R1 is phenyl, naphthyl, a mono or bicyclic heteroaryl group containing up to 3 heteroatoms selected from N, O and S; or a group NR3R4 wherein one of R3 and R4 is hydrogen or optionally substituted (C1-4)alkyl and the other is phenyl, naphthyl or a mono or bicyclic heteroaryl group containing up to 3 heteroatoms selected from N, O and S, or R3 and R4 together with the N atom to which they are attached form a 5 to 7-membered cyclic amine which has an optionally fused phenyl ring; any of which R1 groups may be optionally substituted; R2 represents phenyl or a 5- or 6-membered hereroaryl group containing up to 3 heteroatoms selected from N, O and S, wherein the phenyl or heteroaryl group is substituted by R5, and further optional substituents; or R2 represents an optionally substituted bicyclic aromatic or bicyclic heteroaromatic group containing up to 3 heteroatoms selected from N, O and S; R5 represents an optionally substituted (C1-4)alkoxy, halo, optionally substituted (C1-6)alkyl, optionally substituted phenyl, or an optionally substituted 5- or 6-membered heterocyclic ring containing up to 3 heteroatoms selected from N, O and S; or pharmaceutically acceptable salts thereof.
申请公布号 CA2450922(C) 申请公布日期 2010.02.16
申请号 CA20012450922 申请日期 2001.06.13
申请人 SMITHKLINE BEECHAM P.L.C. 发明人 BRANCH, CLIVE LESLIE;JOHNSON, CHRISTOPHER NORBERT;STEMP, GEOFFREY;THEWLIS, KEVIN
分类号 C07D211/26;A61K31/445;A61K31/4545;A61K31/4709;A61K31/4725;A61K31/498;A61K31/501;A61P1/04;A61P1/08;A61P3/04;A61P3/10;A61P5/02;A61P5/06;A61P5/08;A61P7/00;A61P9/02;A61P9/04;A61P9/10;A61P9/12;A61P11/06;A61P11/16;A61P13/02;A61P13/08;A61P13/12;A61P15/00;A61P15/10;A61P25/04;A61P25/06;A61P25/14;A61P25/16;A61P25/18;A61P25/20;A61P25/22;A61P25/24;A61P25/28;A61P25/30;A61P29/00;A61P35/00;A61P37/08;A61P43/00;C07D401/06;C07D401/10;C07D405/06;C07D405/10;C07D405/14;C07D407/10;C07D409/14;C07D413/06;C07D413/10;C07D413/14;C07D417/06;C07D417/14;C07D471/04 主分类号 C07D211/26
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