| 发明名称 |
RADIOLIGAND AND BINDING ASSAY |
| 摘要 |
The present invention is directed to the radioligand compound, [35S]-radiolabeled (+)-N-[1 -(6-cyano-1,2,3,4-tetrahydro-2(R)-naphthalenyl)-3,4-dihydro-4(R)-hydoxyspiro[2H-1-benzopyran-2,4 -piperidin]-6-yl]methanesulfonamide. Also within the scope of this invention is a method for identifying compounds that bind to the IKr channel, and may have antiarrhythmic activity.
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| 申请公布号 |
CA2415295(C) |
申请公布日期 |
2010.02.16 |
| 申请号 |
CA20012415295 |
申请日期 |
2001.07.10 |
| 申请人 |
MERCK & CO., INC. |
发明人 |
BUTCHER, JOHN W.;CLAREMON, DAVID A.;CONNOLLY, THOMAS M.;DEAN, DENNIS C.;KARCZEWSKI, JERZY;KOBLAN, KENNETH S.;KOSTURA, MATTHEW J.;LIVERTON, NIGEL J.;MELILLO, DAVID G. |
| 分类号 |
C07F7/18;G01N33/566;A61K51/04;C07D491/10;C07D491/107;C07D491/20;C12N15/09;C12Q1/02;G01N33/567;G01N33/58;G01N33/60;G01N33/68 |
主分类号 |
C07F7/18 |
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