发明名称 |
Method of imatinib manufacturing |
摘要 |
A process for the preparation of Imatinib according to the invention consists in converting the 2-methyl-5-halogenoaniline of the Formula 2 into the salt of the 2-methyl-5- halogenophenylguanidine of the Formula 3, which is then condensed with the 3-diaIkylamino- ]-(pyridin-3-yI)prop-2-en-l-one of the Formula 4 to yield the N-(2-methyl-5- halogenophenyl)-4-(pyridin-3-yl)-pyrimidin-2-ylamine of the Formula 5, which is then reacted with 4-(4-methylpiperazin-l-ylmethyl)benzamide of the Formula 6, and the obtained Imatinib is optionally converted into its addition salt. |
申请公布号 |
PL385805(A1) |
申请公布日期 |
2010.02.15 |
申请号 |
PL20080385805 |
申请日期 |
2008.08.01 |
申请人 |
TEMAPHARM SPO&LSTROK,KA Z OGRANICZON&AOGON, ODPOWIEDZIALNO&SACUTE,CI&AOGON, |
发明人 |
GRUZA HENRYK;MIREK S&LSTROK,AWOMIR;JE&ZDOT,EWSKI ARTUR;WRZOSEK ARTUR |
分类号 |
C07D401/04;C07D213/00;C07D239/00;C07D401/14 |
主分类号 |
C07D401/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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