摘要 |
<P>PROBLEM TO BE SOLVED: To provide a method and medicinal composition for treating disorders involving a ceramide-mediated signaling transmission system, for example, those selected from the group consisting of Gaucher disease, Tay-Sachs disease, Sandhoff disease, and Niemann-Pick disease. Ž<P>SOLUTION: Deoxynojirimycin derivatives or their salts contain a large hydrophobic moiety such as adamantanemethanol or cholesterol, linked through a spacer such as pentamethylene, to the nitrogen atom of deoxynojirimycin, and inhibit glucosylceramidase. Ž<P>COPYRIGHT: (C)2010,JPO&INPIT Ž
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