| 发明名称 |
ANTIBODY OF HUMAN ORIGIN FOR INHIBITING THROMBOCYTE AGGREGATION |
| 摘要 |
<P>PROBLEM TO BE SOLVED: To find an antibody having improved characteristics, and to provide a method for identifying the antibody. <P>SOLUTION: The antibody including an scFv (single chain antibody fragment) of human origin inhibits thrombocyte aggregation, and has higher affinity to the activated state of thrombocyte integrin receptor GPIIb/IIIa than to the inactive conformation of the thrombocyte integrin receptor GPIIb/IIIa. <P>COPYRIGHT: (C)2010,JPO&INPIT |
| 申请公布号 |
JP2010029203(A) |
申请公布日期 |
2010.02.12 |
| 申请号 |
JP20090248999 |
申请日期 |
2009.10.29 |
| 申请人 |
AFFIMED THERAPEUTICS AG |
发明人 |
BUETTNER CLAUDIA;KNACKMUSS STEFAN;LITTLE MELVYN;PETER KARLHEINZ;ROETTGEN PETER;SCHWARZ MEIKE |
| 分类号 |
C12N15/02;C12N15/09;A61K31/7088;A61K39/395;A61K48/00;A61P7/02;A61P37/02;C07K16/28;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/13;C12P21/08 |
主分类号 |
C12N15/02 |
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