STEREOSELECTIVE SYNTHESIS OF VALIOLAMINE

摘要

The present invention discloses an intermediate compound for preparing valiolamine and a method for stereoselective synthesis of valiolamine. The intermediate compound possesses chemical structure of formula (21). The said method comprises carbonylating the compound of formula (14) to produce the compound of formula (21), then removing R group and/or hydrolyzing the compound of formula (21) to obtain valiolamine. The obtained valiolamine has a purity of 99% or more. The highly purified valiolamine prepared by a method of the invention can be used for making highly purified voglibose which is medicament for treating diabetes.