发明名称 |
BIOMARKERS AND METHODS FOR DETERMINING SENSITIVITY TO VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2 MODULATORS |
摘要 |
VEGFR-2 biomarkers useful in a method for identifying and monitoring a mammal that will respond therapeutically to a method of treating cancer comprising administering an VEGFR-2 modulator, wherein the method comprises (a) exposing the mammal to the VEGFR-2 modulator and (b) measuring in the mammal the level of the at least one biomarker, wherein a difference in the level of the at least one biomarker measured in (b) compared to the level of the biomarker in a mammal that has not been exposed to the VEGFR-2 modulator indicates that the mammal will respond therapeutically to the method of treating cancer and (c) wherein the level of the biomarker in a mammal after exposure to a VEGFR-2 modulator indicates that the mammal has responded therapeutically to the method of treating cancer
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申请公布号 |
US2010035259(A1) |
申请公布日期 |
2010.02.11 |
申请号 |
US20080450122 |
申请日期 |
2008.03.12 |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
WU SHUJIAN;AYERS MARK DAVID;HAN XIA;YOGANATHAN SUGANTHY;FARGNOLI JOSEPH |
分类号 |
C12Q1/68 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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地址 |
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