PHARMACEUTICAL COMPOSITIONS OF ANALOGUES OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE

摘要

The present invention relates to improvements in compositions containing an analogue of glucose-dependent insulinotropic polypeptide or pharmaceutical salts thereof, and the use of such compositions for treatment of GIP-receptor mediated conditions, such as non-insulin dependent diabetes mellitus and obesity. In particular, the present invention relates to a pharmaceutical composition of a clear aqueous solution, or a gel or a semi-solid, comprising the native GIP, a fragment thereof, an analogue of GIP, or a pharmaceutically acceptable salt thereof (which are collectively referred to as "GIP peptide" or "GIP compound"), and a divalent metal or divalent metal salt component such as ZnCl2 or ZnAc2, in which the clear aqueous solution of the GIP peptide precipitates in vivo at physiological pH to form an in situ deposit that is slowly dissolved and released into the body fluid and bloodstream.