发明名称 |
MANNOSE-6-PHOSPHATE-BINDING ANTIBODIES AND THEIR USES |
摘要 |
<p>The present invention relates to an isolated antibody or antigen-binding fragment thereof which specifically binds to mannose 6-phosphate and methods for preparing such antibody or antigen-binding fragment thereof. The invention further relates to a nucleic acid molecule encoding such antibody or antibody fragment, an expression vector comprising such nucleic acid molecule and a host cell comprising such nucleic acid molecule or expression vector. The invention also relates to a method for purifying or concentrating a target molecule comprising at least one mannose 6-phosphate residue from a sample. In another aspect, the invention relates to a method for diagnosing a disease which is characterized by an absent or reduced modification of molecules with mannose 6-phosphate residues. Finally, the invention relates to the use of an antibody or antibody fragment of the invention for use in medicine, in particular for the diagnosis of a disease which is characterized by an absent or reduced modification of molecules with mannose 6-phosphate residues.</p> |
申请公布号 |
WO2010015683(A1) |
申请公布日期 |
2010.02.11 |
申请号 |
WO2009EP60224 |
申请日期 |
2009.08.06 |
申请人 |
UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF;FORSCHUNGSZENTRUM BORSTEL;BRAULKE, THOMAS;MUELLER-LOENNIES, SVEN |
发明人 |
BRAULKE, THOMAS;MUELLER-LOENNIES, SVEN |
分类号 |
G01N33/53;C07K16/40;C07K16/44 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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