NOVEL METHOD OF PROGNOSIS ASSOCIATED WITH CASES OF POSTPARTUM HAEMORRHAGE

摘要

The present invention relates to an in vitro method of prognosis for the arrest of bleeding in a patient suffering from postpartum haemorrhage in the absence of an invasive procedure, comprising the following steps: (a) determining, using a biological sample from said patient, the plasma fibrinogen concentration, the blood troponin concentration and also the prothrombin time; (b) studying at least two clinical markers for said patient, selected from the group comprising heart rate and the presence of placentation abnormalities; (c) calculating a score Z according to the following equation: Z = a + b + c + d + e; where a is associated with the existence of placentation abnormalities in said patient, with a being 0 when no placentation abnormality is observed in said patient and a being 1 when one or more placentation abnormalities are observed in said patient; where b is associated with the heart rate of said patient, with b being 0 when the heart rate of said patient is less than or equal to 115 bpm (beats per minute) and b being 1 when the heart rate is greater than 115 bpm; where c is associated with the plasma fibrinogen concentration of said patient, with c being 0 when said concentration is greater than or equal to 2 g/L and c being 1 when said concentration is less than 2 g/L; where d is associated with the blood troponin concentration of said patient, with d being 0 when said concentration is less than the detection cut-off and d being 1 when said concentration is greater than or equal to the detection cut-off; where e is associated with the prothrombin time (PT) of said patient, with e being 0 when said prothrombin time is greater than or equal to 50% and e being 1 when said prothrombin time is less than 50%; where a score Z of greater than or equal to a value of 2 is an indication of the need to perform an invasive procedure in order to stop the bleeding in said patient suffering from postpartum haemorrhage.