发明名称 |
ANTI-HEPCIDIN-25 SELECTIVE ANTIBODIES AND USES THEREOF |
摘要 |
Monoclonal antibodies are provided that bind to the N-terminus of human hepcidin-25 and are characterized as having high affinity and selectivity for the polypeptide. The antibodies of the invention are useful for increasing serum iron levels, reticulocyte count, red blood cell count, hemoglobin, and/or hematocrit in a human and for the treatment of various disorders, such as anemia, in a human subject. The antibodies of the invention are also useful as analytical tools, such as in sandwich ELISA.
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申请公布号 |
CA2733497(A1) |
申请公布日期 |
2010.02.11 |
申请号 |
CA20092733497 |
申请日期 |
2009.07.29 |
申请人 |
ELI LILLY AND COMPANY |
发明人 |
LEUNG, DONMIENNE DOEN MUN;LUAN, PENG;TANG, YING;WITCHER, DERRICK RYAN;YACHI, PIA PAULIINA |
分类号 |
C07K16/26;A61K39/395;A61P7/06;G01N33/577 |
主分类号 |
C07K16/26 |
代理机构 |
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