The invention relates to crystalline forms of flupirtine, particularly to 1:1 flupirtine hydrochloride maleic acid cocrystal. The preparation and characterization of 1:1 flupirtine hydrochloride maleic acid cocrystal is described. The invention also relates to the therapeutic use of the flupirtine hydrochloride maleic acid cocrystal to treat nervous system disorders, pain disorders, and musculoskeletal disorders and to pharmaceutical compositions containing the cocrystal.
申请公布号
CA2738866(A1)
申请公布日期
2010.02.11
申请号
CA20092738866
申请日期
2009.08.06
申请人
BIONEVIA PHARMACEUTICALS, INC.
发明人
KALOFONOS, ISABEL;STAHLY, G. PATRICK;MARTIN-DOYLE, WILLIAM;KALOFONOS, DIMITRIS;STULTS, JEFFREY S.;HANKO, JASON A.;SHIPPLETT, REX A.