发明名称 |
AMINO ACID AND PEPTIDE PRO-DRUGS OF PHENOLIC ANALGESICS AND USES THEREOF |
摘要 |
Prodrugs of meptazinol and other phenolic analgesics exhibiting low oral bioavailability with amino acids or lower peptides, pharmaceutical compositions containing such prodrugs and a method for providing pain relief with such prodrugs are provided. In addition, the present invention relates to methods for increasing the oral bioavailability of a phenolic analgesic. The method comprises orally administering a phenolic analgesic prodrug, wherein the phenolic analgesic is bound to an amino acid or peptide via a carbamate linkage, to a subject in need thereof. Prodrugs having side chains of valine, leucine, isoleucine and glycine amino acids and mono-, di - and tripeptides thereof are preferred. |
申请公布号 |
WO2009092071(A3) |
申请公布日期 |
2010.02.11 |
申请号 |
WO2009US31404 |
申请日期 |
2009.01.19 |
申请人 |
SHIRE LLC;FRANKLIN, RICHARD;GOLDING, BERNARD, T.;TYSON, ROBERT, G. |
发明人 |
FRANKLIN, RICHARD;GOLDING, BERNARD, T.;TYSON, ROBERT, G. |
分类号 |
A61K47/48;A61P25/04;C07D223/04;C07D489/08;C07D489/12 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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