| 摘要 |
The invention relates to novel anti-bacterial 15-membered 6-O-substituted-8a-aza-8a- homoerythromycin A and 6-O-substituted-9a-aza-9a-homoerythromycin A, their 6-O- substituted-3-O-decladinosyl-3-oxy and 6-O-substituted-3-O-decladinosyl-3-oxo compound of the general formula (I), wherein A represents NH; and B simultaneously represents -C(O)-, or A represents -C(O)- and B simultaneously represents NH; R4 represents: a straight or branched chain C3-C7 alkyl group containing a moiety selected from piperazin-1,4-yl, 2-methyl-piperazin-1,4-yl, 2-methyl-piperazin-1,4-yl-S(O)2, NH and N(CH3), or containing two NH moieties; wherein the second alkyl carbon atom is substituted by a hydroxy substituent, and the terminal carbon atom or heteroatom is substituted by phenyl (itself optionally substituted); or prop-2-enyl (i.e. allyl) optionally substituted by naphthyl or quinolinyl; or CH2-oxiranyl group; and R5 represents (a) dimethylamino [-N(CH3)2] or (b) dimethylamino-N-oxide [-N(O)(CH3)2] group. |
