This invention provides a unique composition which includes a DNA dendrimer combined with siRNA molecule. Further, methods of preparing a composition which includes a DNA dendrimer combined with a siRNA molecule, methods of protecting a DNA dendrimer siRNA complex against degradation in body fluids, methods of protecting a DNA dendrimer against degradation in bodily fluids, and methods of delivering a DNA dendrimer into bodily fluids are provided.
申请公布号
WO2010017544(A2)
申请公布日期
2010.02.11
申请号
WO2009US53264
申请日期
2009.08.10
申请人
GENISPHERE, INC.;KADUSHIN, JAMES, M.;GETTS, ROBERT, C.