VACCINES AGAINST CLOSTRIDIUM DIFFICILE AND METHODS OF USE

摘要

Attenuated microorganisms expressing Clostridium difficile ant?gen(s), and methods of using the same for vaccination of patients are disclosed The invention provides an attenuated microorganism expressing an immunogenic portion of a C difficile Toxin A C-terminal repeat region and/or a C difficile Toxin B C-terminal repeat region The microorganism is an attenuated Salmonella comprising an integrated gene expression cassette that directs the expression of the immunogenic peptide from an in vivo inducible promoter.