| 摘要 |
<p>A novel and practical process for selectively producing a pyridobenzoxazine carboxylic acid hemihydrate (e.g., (S)-9-fluoro-3-methyl-10-(4-methyl-l-piperazinyl)-7-oxo- 2, 3-dihydro-7H-pyrido- [1, 2, 3-de] [1, 4] benzoxazine-6-carboxylic acid hemihydrate) in high yield via crystallization from an organic solvent or a mixed organic solvent system containing a calculated amount of water released from sodium sulfate decahydrate under gradually heating.</p> |
| 申请人 |
APELOA-KANGYU;WANG, ZHEQING;SHU, LIJIAN;GUO, WEIFENG;ZHU, HANG, CHANG;YANG, PINGAI;SHEN, XIAOFENG;JIN, CHENMING |
发明人 |
WANG, ZHEQING;SHU, LIJIAN;GUO, WEIFENG;ZHU, HANG, CHANG;YANG, PINGAI;SHEN, XIAOFENG;JIN, CHENMING |
