NON-HUMAN TRANSGENIC MAMMALS USED AS MODELS FOR HUMAN PATHOLOGIES ORIGINATING FROM STEM CELLS

摘要

The invention relates to non-human transgenic mammals which reproduce human pathologies originating from stem cells, e.g. chromosomal anomalies associated with chronic myeloid leukaemia, B-cell lineage acute lymphoblastic leukaemia, T-cell lineage acute lymphoblastic leukaemia, or the migration of hematopoietic or embryonic stem cells. The invention makes use of the expression of the genes involved in said pathology in human beings, employing a promoter which directs the expression of a transgene in cells Sca-1+. The aforementioned transgenic animals form a model which is used to study the above-mentioned diseases and to evaluate compounds for treating and/or preventing said diseases.