Pyrazole carboxamides as inhibitors of 11-beta-hydroxysteroid dehydrogenase-1

摘要

Pyrazole carboxamides of structural formula I are selective inhibitors of the 11beta-hydroxysteroid dehydrogenase-1. The compounds are useful for the treatment of diabetes, such as noninsulin-dependent diabetes (NIDDM), hyperglycemia, obesity, insulin resistance, dyslipidemia, hyperlipidemia, hypertension, Metabolic Syndrome, and other symptoms associated with NIDDM.