发明名称 |
STABILIZATION OF AQUEOUS COMPOSITIONS OF PROTEINS WITH DISPLACEMENT BUFFERS |
摘要 |
An aqueous composition having increased protein stability is obtained by: a. determining a pH at which the protein has stability at the desired temperature; b. adding to the composition at least one displacement buffer wherein the displacement buffer has a pKa that is at least 1 unit greater or less than the pH of step (a); and c. adjusting the pH of the composition to the pH of step (a); wherein the aqueous composition does not comprise a conventional buffer at a concentration greater than about 2 mM and wherein the conventional buffer has a pKa that is within 1 unit of the pH of step (a).
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申请公布号 |
US2010028372(A1) |
申请公布日期 |
2010.02.04 |
申请号 |
US20090492411 |
申请日期 |
2009.06.26 |
申请人 |
JEZEK JAN |
发明人 |
JEZEK JAN |
分类号 |
A61K39/00;C07K14/00;C07K14/52;C07K14/575;C07K14/61;C07K14/62;C07K14/745;C07K14/755;C07K16/00;G01N33/00 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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