发明名称 |
T cell regulation |
摘要 |
Regulatory T cells (Treg) limit autoimmunity but can also attenuate the magnitude of anti-pathogen and anti-tumor immunity. Understanding the mechanism of Treg function and therapeutic manipulation of Treg in vivo requires identification of Treg selective receptors. A comparative analysis of gene expression arrays from antigen specific CD4+ T cells differentiating to either an effector/memory or a regulatory phenotype revealed Treg selective expression of LAG-3 (CD223), a CD4-related molecule that binds MHC class II. LAG-3 expression on CD4+ T cells correlates with the cells' in vitro suppressor activity, and ectopic expression of LAG-3 on CD4 T cells confers suppressor activity on the T cells. Antibodies to LAG-3 inhibit suppression both in vitro and in vivo. LAG-3 marks regulatory T cell populations and contributed to their suppressor activity. |
申请公布号 |
AU2004217526(B2) |
申请公布日期 |
2010.02.04 |
申请号 |
AU20040217526 |
申请日期 |
2004.03.01 |
申请人 |
THE JOHNS HOPKINS UNIVERSITY;ST. JUDE CHILDREN'S RESEARCH HOSPITAL INC. |
发明人 |
GREG J. WORKMAN;JONATHAN POWELL;CHING-TAI HUANG;CHARLES C. DRAKE;DARIO A. VIGNALI;DREW M. PARDOLL |
分类号 |
A01N43/04;A61K31/70;A61K35/12;A61K39/00;A61K39/38;A61K39/395;C07K16/00;C07K16/28;C12N;C12N5/0783;C12P21/08;G01N33/53 |
主分类号 |
A01N43/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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