EFFICIENT METHOD FOR ESTABLISHING INDUCED PLURIPOTENT STEM CELLS

摘要

The present invention provides a method of producing induced pluripotent stem (iPS) cells, comprising bringing a nuclear reprogramming substance into contact with dental pulp stem cells. By using dental pulp stem cells as a source of somatic cells, the efficiency of establishment of human iPS cells by transfer of 3 or 4 factors can be improved dramatically. Additionally, dental pulp stem cells are easily available because they can be isolated and prepared from extracted wisdom teeth and teeth extracted because of periodontal disease and the like, so that they can be used widely as a source of somatic cells for iPS cell banks.