| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide antibody molecules for treating NHL (non-Hodgkin lymphoma), repeatedly usable and easily and efficiently producible. <P>SOLUTION: There is provided an antibody containing at least one CDR (Complementarity Determining Region) derived from a mouse monoclonal antibody having specificity for CD22. Also provided is a CDR grafted antibody wherein at least one of the CDRs is a modified CDR. Further provided are DNA sequences encoding the chains of the antibody molecules, vectors, transformed host cells and use of the antibody molecules in the treatment of diseases mediated by cells expressing CD22. <P>COPYRIGHT: (C)2010,JPO&INPIT |
