| 发明名称 |
HER2/NEU SPECIFIC T CELL RECEPTORS |
| 摘要 |
<p>The present invention is directed to T cell receptors (TCR) recognizing antigenic peptides derived from Her2/neu, in particular peptide 369, and being capable of inducing peptide specific killing of a target cell overexpressing HER2/neu. The present invention is further directed to an antigen specific T cell, comprising said TCR, to a nucleic acid coding for said TCR and to the use of the antigen specific T cells for the manufacture of a medicament for the treatment of malignancies characterized by overexpression of HER2/neu. The present invention is further disclosing a method of generating antigen specific T cells.</p> |
| 申请公布号 |
WO2010012829(A1) |
申请公布日期 |
2010.02.04 |
| 申请号 |
WO2009EP59953 |
申请日期 |
2009.07.31 |
| 申请人 |
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT (GMBH);KRACKHARDT, ANGELA;WEIGAND, LUISE;LIANG, XIAOLING |
发明人 |
KRACKHARDT, ANGELA;WEIGAND, LUISE;LIANG, XIAOLING |
| 分类号 |
C07K14/705;A61K48/00;C12N5/10;C12N15/63 |
主分类号 |
C07K14/705 |
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