CB1 RECEPTOR MODULATORS

摘要

Compounds of formula (I) suppress the normal signalling activity of cannabinoid receptor CB1 and are therefore useful inter alia in the treatment of conditions directly or indirectly associated with obesity and overweight, Wherein A1 is -COOH or tetrazolyl; R2, R3, R'2 and R'3 are independently selected from -R9, - CN, -F1 -Cl, -Br, -OR9, or -SR9; R9 is hydrogen, C1-C3 alkyl, cycloalkyl, or fully or partially fluorinated C1-C3 alkyl; R1 is (i) a bond, or (H) -C(R10)(R11)-*. -C(R10)(R11)-O-*. -C(R10)(R11)CH2*, or -CH2C(R10)(R11)-*, wherein the bond indicated by an asterisk is attached to Ring A ring; R10 is hydrogen and R11 is hydrogen, (C1-C3)alkyl or -OH; or R10 and R11 are both (C1-C3)alkyl; or R10 and R11 taken together with the carbon atom to which they are attached form a (C3-C5)cycloalkyl ring; Ring A is an aromatic ring as specified in the claims; Z1 is a moncyclic group as specified in the claims.